The SentroPAT DA is a dedicated NIR analyzer for non-invasive online monitoring of pharmaceutical powder bin blending. The system provides valuable process insight from product development to operations and can also be used to control blend time.
This extremely compact system with its very low weight fits many sizes of blenders.
High Performance Diode Array Spectrometer
The heart of the instrument is a rugged and proven InGaAs diode array spectrometer. High spectral resolution and wavelength
accuracy combined with low noise enable the use in demanding applications. Superior system-to-system comparability
simplifies method transfer between instruments. High long-term and temperature stability is supported by internal intensity
and wavelength standards.
Understand and Control the Blending Process
In addition to determining the blending end-point by statistical methods, it is possible to also perform quantitative analysis
of the potency of APIs or other blend constituents using chemometric models. Based on the process knowledge gained
through NIR analysis, it is possible to optimize blend time, avoid faulty batches and prevent segregation due to over-blending.
There is no longer a need for conventional sampling and laboratory analysis, which impede manufacturing processes
and therewith raise production costs. Fully implemented and applied, the online monitoring of blend uniformity is a key
element for real-time release.
Flexibility and Ease of Handling
Focus areas of design and development from the very outset were ease-of-use and minimum maintenance time:
- Mounting to the blender is done by means of a simple 2” or 4” sanitary flange.
- Recharge the battery using the system’s power adapter.
- The internal 3-axis accelerometer allows software adjustable and reliable measurement synchronization to the blender rotation.
- The smooth surfaces of the unit can be easily cleaned, as it is required for use in GMP production facilities.
Highest Data Integrity
Data integrity is supported by the embedded system, where all generated data are buffered locally on the analyzer, before
transmission through the WiFi connection. The system supports integration to plant level IT and controls via OPC-server or
interfaces to SIPAT or SynTQ.